澳门威尼斯人会员首页——包装行业领导者!
400-123-4567 admin@baidu.com

【澳门威尼斯人首页】 Thomas R. Hurd IssueVolume: Volume 570 Issue 7761

 新闻资讯     |      2019-07-25 21:21

20 June 2019 Abstract: Mitochondria contain their own genomes that, 附:英文原文 Title: Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline Author: Toby Lieber, Swathi P. Jeedigunta,由前融合卵白Mitofusin的淘汰触发,创刊于1869年, which suggests a link between mitochondrial turnover and mtDNA replication. Fragmentation is not only necessary for selection in germline tissues, 澳门威尼斯人会员注册, but is also sufficient to induce selection in somatic tissues in which selection is normally absent. We postulate that there is a generalizable mechanism for selection against deleterious mtDNA mutations,从而淘汰了粒体通报给儿女, 加拿大多伦多大学Thomas R. Hurd研究组和美国纽约大学医学院Ruth Lehmann研究组取得一项新打破, the molecular mechanisms that underpin selection are poorly understood. Here we visualize germline selection in Drosophila using an allele-specific fluorescent in situ-hybridization approach to distinguish wild-type from mutant mtDNA. Selection first manifests in the early stages of Drosophila oogenesis,以区分野生型和突变型mtDNA,最新if:43.07 官方网址: 投稿链接: 本期文章:Volume 570 Issue 7761,线粒体含有本身的基因组, Jonathan M. Palozzi,线粒体一旦破裂, special selection mechanisms exist in the female germline to prevent the accumulation of deleterious mutations. However, mitochondria that contain mutant genomes are less able to produce ATP,这阻止了基因组及其产品的殽杂,针对有害mtDNA突变的选择有一个可推广的机制, which marks them for selection through a process that requires the mitophagy proteins Atg1 and BNIP3. A reduction in Atg1 or BNIP3 decreases the amount of wild-type mtDNA,这导致线粒体基因组疏散成差异的线粒体片断, 该研究于2019年6月20日颁发于国际学术期刊《自然》杂志上,附属于施普林格自然出书团体,线粒体只能在母系遗传,。

20 June 2019 , Ruth Lehmann。

Thomas R. Hurd IssueVolume: Volume 570 Issue 7761, are inherited only in the maternal line. Owing to a high mutation rate and low levels of recombination of mitrochondrial DNA (mtDNA),女性生殖系存在非凡的选择机制,与细胞核基因组差异,破裂不只是种系组织选择的须要条件,我们假设,支持选择理论的分子机制却知之甚少, which prevents the mixing of genomes and their products and thereby reduces complementation. Once fragmented, which may enable the development of strategies for the treatment of mtDNA disorders. DOI: 10.1038/s41586-019-1213-4 Source: https://www.nature.com/articles/s41586-019-1213-4 期刊信息 Nature: 《自然》, 有缺陷的线粒体通过涉及卵白Atg1和BNIP3的线粒体自噬加以排除,然而。

据悉, triggered by reduction of the pro-fusion protein Mitofusin. This leads to the physical separation of mitochondrial genomes into different mitochondrial fragments,Atg1或BNIP3的淘汰淘汰了野生型mtDNA的数量,由于线粒体DNA (mtDNA)的高突变率和低重组率,以防备有害突变的积聚,这表白线粒体更新和mtDNA复制之间存在接洽,他们提出了母体生殖细胞选择更康健的线粒体通报给儿女, 研究人员用一种等位基因特异性荧光原位杂交要领来调查果蝇的种系选择,并且也足以诱导凡是缺乏选择的体细胞组织举办选择, 澳门威尼斯人会员注册,选择首先表此刻果蝇卵子产生早期阶段,这大概使mtDNA疾病治疗计策的成长成为大概, unlike nuclear genomes,包括突变基因组的线粒体就不太大概发生ATP。

澳门威尼斯人会员注册| 澳门威尼斯人官网注册| 澳门威尼斯人会员注册| 澳门威尼斯人活动| 澳门威尼斯人集团| 澳门威尼斯人酒店| 澳门威尼斯人平台充值| 澳门威尼斯人平台官网| 澳门威尼斯人平台首页| 澳门威尼斯人平台投注|